UNITED NEWS INTERNATIONAL (UNI) — Suicide rates are up in the United States.

A study published June 7 by the U.S. Centers for Disease Control found the number of self-inflicted deaths increased by about 25 percent across the nation from 1999 to 2016.

Suicides increased by more than 30 percent in half of U.S. states.

The state of Montana recorded the most suicides, with 29 for every 100,000 people, while the District of Columbia reported the lowest, with about 7 suicides per 100,000 people.

Nearly 45,000 Americans aged 10 or older took their own lives in 2016 alone.

The analysis found that more than half of people who committed suicide did not have any known mental health conditions. However, researchers said other factors in their lives like the loss of a relationship, financial setbacks, substance use, eviction and social isolation contributed to suicides.